| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-545 |
| Biological function: |
Promotes GC cell proliferation, invasion, metastasis-related ability, and inhibits apoptosis. |
| Molecular mechanism: |
circ-PRKCI acts as a sponge for microRNA-545, binds microRNA-545, and inhibits its expression in GC cells. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Nuclear-Cytoplasmic Fractionation |
| Clinical significance: |
High expression of circ-PRKCI is associated with poor prognosis, TNM staging, and tumor metastasis in GC patients; circ-PRKCI can be used as a potential prognostic indicator of GC. |
| Description: |
circ-PRKCI (hsa_circ_0067934) is up-regulated in gastric cancer tissues and cell lines. Its high expression predicts poor prognosis and is associated with TNM stage and metastasis. Functionally, circ-PRKCI promotes GC cell proliferation and invasion while inhibiting apoptosis, mainly by binding/sponging microRNA-545. |
| Confidence score: |
0.7617 |