| Expression pattern: |
DN |
| Associated gene: |
TUSC1 |
| Associated microRNA: |
miR-4701-5p |
| Biological function: |
circ_PLXNB1 inhibits CRC cell proliferation, invasion, migration and EMT, induces G1-phase cell-cycle arrest, and impedes xenograft tumor growth. |
| Molecular mechanism: |
circ_PLXNB1 functions as a ceRNA by binding miR-4701-5p, thereby upregulating TUSC1 and inactivating the TGF-beta/Smad pathway to suppress CRC progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); cell cycle (other); TGF-beta/SMAD (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Transfection; MTT; Cell Cycle Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
circ_PLXNB1 has close association with distant metastasis and lymph node metastasis in CRC patients. |
| Description: |
circ_PLXNB1/hsa_circ_0065378 is downregulated in colorectal cancer tissues and cell lines. Its overexpression suppresses CRC proliferation, invasion, migration, EMT and xenograft tumor growth by sponging miR-4701-5p, increasing TUSC1, and inactivating the TGF-beta/Smad pathway. Clinically, circ_PLXNB1 expression is associated with distant metastasis and lymph node metastasis. |
| Confidence score: |
0.8351 |