circRNA basic information
circBase ID: hsa_circ_0001588
Name: hsa_circ_HIST1H4E
Synonym: hsa_circRNA_001588 / circ_0001588
Host Gene: HIST1H4E
Genomic location(hg19): chr6:26204839-26205043:+
Genomic location(hg38): chr6:26204611-26204815:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004605
MONDO name: chronic ulcer of skin
Disease details: chronic diabetic extremity wounds / diabetic chronic refractory wounds / diabetes refractory wounds
Disease DO ID:
 8549
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

chronic diabetic wounds; adjacent normal skin tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-514a-3p
Biological function: unknown
Molecular mechanism: Predicted ceRNA/circRNA-miRNA interaction with hsa-miR-514a-3p in diabetic wound ceRNA network.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_001588 (hsa_circ_0001588) is up-regulated in chronic diabetic wound tissue and is included in the predicted diabetic-wound ceRNA network. It is linked to miR-514a-3p regulation in the network, suggesting a circRNA-miRNA interaction relevant to wound-healing dysregulation in diabetes.
Confidence score:

0.348
Other information
Title:

Screening and analysis of differentially expressed circRNAs and miRNAs in chronic diabetic extremity wounds.

Journal: Frontiers in surgery
Published: 2022
PubMed ID: 36439541
Study type:

combined biological and clinical study
Data availability: GEO GSE212167
Code availability: -