| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
May act as a potential diagnostic biomarker for CAD; high expression combined with hypertension enhances CAD risk. |
| Molecular mechanism: |
m6A-modified circRNA profile alteration and circRNA-environment interaction with hypertension; exact molecular mechanism was not demonstrated. |
| Biological pathway or process: |
m6A modification (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; MeRIP / MeRIP-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Significantly increased in patients with CAD; may act as a potential diagnostic biomarker; ROC AUC was 0.630; positively interacted with hypertension to enhance CAD risk. |
| Description: |
hsa_circHECTD1 is an m6A-modified circRNA derived from HECTD1 and is significantly up-regulated in ox-LDL-treated HCASMCs and PBMCs from CAD patients. The study supports its potential clinical value as a CAD diagnostic biomarker and shows a positive interaction with hypertension in increasing CAD risk, although its detailed molecular mechanism was not functionally demonstrated. |
| Confidence score: |
0.729 |