circRNA basic information
circBase ID: -
Name: hsa_circ_RPS6KC1
Synonym: circRNA-100451 / hsa_circRNA_100451
Host Gene: RPS6KC1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004605
MONDO name: chronic ulcer of skin
Disease details: chronic diabetic extremity wounds
Disease DO ID:
 8549
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

chronic diabetic wounds; adjacent normal skin tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-200b-3p
Biological function: unknown
Molecular mechanism: Predicted involvement in ceRNA network (circRNA-miRNA interaction) in diabetic wound tissue.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circRNA-100451 (hsa_circRNA_100451) is down-regulated in chronic diabetic wound tissue versus adjacent normal skin and was validated by RT-qPCR consistent with RNA-seq. It is included as part of a predicted circRNA-miRNA ceRNA network (interaction predicted with hsa-miR-200b-3p).
Confidence score:

0.4032
Other information
Title:

Screening and analysis of differentially expressed circRNAs and miRNAs in chronic diabetic extremity wounds.

Journal: Frontiers in surgery
Published: 2022
PubMed ID: 36439541
Study type:

combined biological and clinical study
Data availability: GEO GSE212167
Code availability: -