| Expression pattern: |
UP |
| Associated gene: |
HN1 |
| Associated microRNA: |
miR-485-5p |
| Biological function: |
circSCMH1 promotes sorafenib resistance, cell proliferation, migration, invasion, and glucose metabolism, and inhibits apoptosis in sorafenib-resistant HCC cells; circSCMH1 depletion inhibits tumor growth and increases sorafenib sensitivity in vivo. |
| Molecular mechanism: |
circSCMH1 functions as a ceRNA by sponging miR-485-5p to upregulate HN1 expression, thereby promoting sorafenib resistance in HCC cells. |
| Biological pathway or process: |
drug resistance (promotes); chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circSCMH1 is elevated in SOR-resistant HCC tissues and may provide a circRNA-targeted therapeutic strategy to overcome sorafenib resistance in HCC. |
| Description: |
circSCMH1 is up-regulated in sorafenib-resistant HCC tissues and cells. It promotes sorafenib resistance and malignant phenotypes by acting as a ceRNA for miR-485-5p, thereby upregulating HN1; circSCMH1 knockdown increases sorafenib sensitivity in vitro and in a Huh7/SOR xenograft model. |
| Confidence score: |
0.8443 |