| Expression pattern: |
UP |
| Associated gene: |
CFL2, E-cadherin, N-cadherin, Ago2 |
| Associated microRNA: |
miR-153-3p |
| Biological function: |
Promotes breast cancer cell proliferation, colony formation, migration, invasion, metastasis and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0008673 acts as a ceRNA by sponging miR-153-3p to upregulate CFL2 expression, thereby promoting breast cancer malignancy. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0008673 has potential as a predictive biomarker or therapeutic target for breast cancer. |
| Description: |
circ_0008673 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT-like marker changes and in vivo tumor growth while inhibiting apoptosis, mainly through sponging miR-153-3p to increase CFL2 expression. The authors propose circ_0008673 as a potential predictive biomarker or therapeutic target for breast cancer. |
| Confidence score: |
0.7799 |