| Expression pattern: |
UP |
| Associated gene: |
IL-6 |
| Associated microRNA: |
miR-370 |
| Biological function: |
Promotes CRC cell proliferation and cisplatin resistance (chemoresistance). |
| Molecular mechanism: |
Acts as a ceRNA by sequestering miR-370, thereby relieving repression of IL-6 and enhancing cisplatin resistance. |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; MTT; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circRNA_101277 expression is associated with worse overall survival and can discriminate between tumor and adjacent tissues. |
| Description: |
circRNA_101277 is upregulated in colorectal cancer and promotes tumor cell proliferation and cisplatin resistance. Mechanistically, it sponges miR-370 to upregulate IL-6, forming a circRNA_101277/miR-370/IL-6 ceRNA axis linked to poor overall survival and diagnostic discrimination between tumor and adjacent tissues. |
| Confidence score: |
0.7449 |