| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Subtype-discriminating TNBC marker candidate; discussed as pathophysiologically relevant to cytoskeletal remodeling/metastatic potential (via host-gene context). |
| Molecular mechanism: |
Subtype-specific m6A hypomethylation with downregulation; mechanistic implications discussed via enriched pathways (no direct interaction assays for this circRNA). |
| Biological pathway or process: |
other pathway/process (other) |
| Detected method: |
M
|
| Validation methods: |
MeRIP / MeRIP-seq; Microarray; RNase R Treatment; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
High discriminatory power for TNBC vs luminal (AUC TNBC vs. Luminal = 1.0). |
| Description: |
hsa_circRNA_404557 (VAV3 circRNA) is reported as hypomethylated and downregulated in TNBC, with very high diagnostic discrimination (AUC = 1.0) between TNBC and luminal tumors. Its functional relevance is discussed mainly through host-gene/pathway context (e.g., CDC42/Rho GTPase-related programs), without direct mechanistic validation for this circRNA. |
| Confidence score: |
0.5668 |