| Expression pattern: |
DN |
| Associated gene: |
PSME1, FERMT3, GRK2, OS9, NLRX1 |
| Associated microRNA: |
miR550a-5p, miR550a-3-5p, miR-550a-5p, miR-550a-3-5p |
| Biological function: |
Acts as an upstream ceRNA component; reduced expression decreases miRNA binding, enhancing miRNA-mediated repression of downstream mRNAs linked to inflammatory responses in gouty arthritis. |
| Molecular mechanism: |
ceRNA mechanism via binding miR-550a-5p and miR-550a-3-5p to modulate downstream targets (e.g., GRK2, PSME1, FERMT3, OS9). |
| Biological pathway or process: |
ceRNA regulation (other); inflammation (promotes); chemokine signaling (other); NF-kappaB (other); pyroptosis (other); NLRP3 inflammasome (other pathway/process) |
| Detected method: |
S
|
| Validation methods: |
circRNA-seq; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
novel_circ_0030384 is a downregulated upstream circRNA in a co-regulated ceRNA network in gouty arthritis. Its reduced abundance is proposed to weaken miRNA sponging (miR-550a-5p/miR-550a-3-5p), thereby enhancing repression of inflammatory-related mRNA targets such as GRK2, PSME1, FERMT3 and OS9 and contributing to inflammation via chemokine-associated processes. |
| Confidence score: |
0.2414 |