circRNA basic information
circBase ID: hsa_circ_0040039
Name: hsa_circ_SNTB2
Synonym: circSNTB2
Host Gene: SNTB2
Genomic location(hg19): chr16:69279504-69318147:+
Genomic location(hg38): chr16:69245601-69284244:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; peritumoral tissue; gastric cancer tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: G0S2, PDCD4
Associated microRNA: miR-6938-5p, hsa-miR-6838-5p
Biological function: Inhibits gastric cancer tumorigenesis (tumor-suppressive role inferred from down-regulation and stated inhibitory implication).
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-6938-5p, thereby modulating expression of G0S2 and PDCD4.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis
Clinical significance:

CircSNTB2 could be a promising biomarker for GC diagnosis and targeted therapy.
Description:

circSNTB2 (hsa_circ_0040039) is significantly down-regulated in gastric cancer tissues. It is proposed to act as a ceRNA that sponges miR-6938-5p, thereby affecting downstream target genes G0S2 and PDCD4 and influencing GC tumorigenesis, with potential biomarker value for GC diagnosis/therapy.
Confidence score:

0.2465
Other information
Title:

Gastric Cancer Growth Modulated by circSNTB2/miR-6938-5p/G0S2 and PDCD4.

Journal: Combinatorial chemistry & high throughput screening
Published: 2023
PubMed ID: 36366842
Study type:

combined biological and clinical study
Data availability: GSE78092; GSE124158
Code availability: -