circRNA basic information
circBase ID: hsa_circ_0002768
Name: hsa_circ_MYLK
Synonym: circMYLK
Host Gene: MYLK
Genomic location(hg19): chr3:123471177-123512691:-
Genomic location(hg38): chr3:123752330-123793844:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow; CD34+ cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CIITA
Associated microRNA: -
Biological function: associated with immune evasion during AML relapse after transplantation
Molecular mechanism: downregulation associated with inhibition of HLA class II regulator CIITA expression
Biological pathway or process:

immune regulation (promotes); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

potential biomarker for post-transplant relapse
Description:

In relapsed AML after allo-HSCT, hsa_circ_0002768 (circMYLK) is down-regulated and is linked to immune evasion. The study associates circMYLK downregulation with reduced expression of the HLA class II regulator CIITA.
Confidence score:

0.4032
Other information
Title:

Deregulated Expression of Circular RNAs Is Associated with Immune Evasion and Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.

Journal: Genes
Published: 2022
PubMed ID: 36360223
Study type:

combined biological and clinical study
Data availability: The raw data supporting the conclusion of the present article will be made available by the author.
Code availability: -