circRNA basic information
circBase ID: -
Name: hsa_circ_LAMP1
Synonym: hsa_circ_101303 / hsa_circRNA101303
Host Gene: LAMP1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissues; adjacent tissues; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: LAMP1, 27 genes
Associated microRNA: hsa-miR-139-3p, hsa-miR-146b-3p, hsa-miR-338-3p, hsa-miR-127-5p, hsa-miR-326, hsa-miR-330-5p, hsa-miR-663b, hsa-miR-940, hsa-miR-767-5p
Biological function: Associated with CRC progression; potential oncogenic role; potential diagnostic biomarker in plasma
Molecular mechanism: ceRNA network constructed linking hsa_circ_101303 to nine miRNAs and downstream genes
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

High expression associated with advanced N stage, M stage, and tumor stage; plasma levels elevated in CRC and show moderate diagnostic ability (AUC = 0.738)
Description:

hsa_circ_101303 is up-regulated in colorectal cancer tissues and is also elevated in patient plasma, showing moderate diagnostic performance (AUC 0.738). The study builds a predicted ceRNA network in CRC linking hsa_circ_101303 to nine miRNAs and downstream genes, suggesting a potential regulatory role in CRC progression.
Confidence score:

0.5047
Other information
Title:

Identification and diagnostic potential of hsa_circ_101303 in colorectal cancer: unraveling a regulatory network.

Journal: BMC cancer
Published: 2024
PubMed ID: 38824581
Study type:

combined biological and clinical study
Data availability: GSE126094; GSE138589; GSE142837; GSE97332; GSE100186; TCGA-COADREAD
Code availability: -