| Expression pattern: |
UP |
| Associated gene: |
HIF-1alpha |
| Associated microRNA: |
miR-542-3p |
| Biological function: |
Promotes glycolysis and proliferation and inhibits apoptosis of breast cancer cells under hypoxia; its downregulation suppresses BCa progression. |
| Molecular mechanism: |
circRBM33 sponges miR-542-3p and thereby regulates HIF-1alpha expression, affecting hypoxia-induced glycolysis and apoptosis/proliferation in BCa cells. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circRBM33 is up-regulated in breast cancer tissues/cell lines and further induced by hypoxia. Functionally, circRBM33 promotes glycolysis and proliferation and inhibits apoptosis in BCa cells by sponging miR-542-3p, thereby increasing HIF-1alpha expression. |
| Confidence score: |
0.6996 |