| Expression pattern: |
UP |
| Associated gene: |
LASP1, Bax, MMP9 |
| Associated microRNA: |
miR-873-5p |
| Biological function: |
circ_0001615 promotes CRC cell proliferation and migration, inhibits apoptosis, supports tumor growth in vivo, and attenuates the anti-cancer effects of AS-IV. |
| Molecular mechanism: |
circ_0001615 acts as a ceRNA by sponging miR-873-5p to positively regulate LASP1 expression, thereby modulating AS-IV-mediated CRC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0001615 might act as a biomarker in the treatment process of AS-IV for CRC. |
| Description: |
circ_0001615 is up-regulated in CRC tissues and cell lines and functions as an oncogenic circRNA that promotes proliferation, migration, and tumor growth while inhibiting apoptosis. AS-IV suppresses CRC progression partly by downregulating circ_0001615, which relieves circ_0001615-mediated sponging of miR-873-5p and reduces LASP1 expression. |
| Confidence score: |
0.7552 |