circRNA basic information
circBase ID: hsa_circ_0023404
Name: hsa_circ_RNF121
Synonym: circ_0023404
Host Gene: RNF121
Genomic location(hg19): chr11:71668272-71671937:+
Genomic location(hg38): chr11:71957226-71960891:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011962
MONDO name: endometrial cancer
Disease details: endometrial cancer / EC
Disease DO ID:
 1380
Disease MeSH ID:
 -
Disease NCIt ID:
 C27815
Disease ICD11 ID:
 -
Disease OMIM ID:
 608089
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HEEC; Ishikawa; RL95-2; KLE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MARK1
Associated microRNA: miR-217
Biological function: promotes proliferation; promotes migration; promotes invasion
Molecular mechanism: Acts as a miRNA sponge for miR-217, relieving miR-217-mediated repression of MARK1.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot
Clinical significance:

-
Description:

hsa_circ_0023404 is up-regulated in endometrial cancer cell lines and promotes proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA that sponges miR-217, leading to increased MARK1 expression and enhanced malignant phenotypes in vitro.
Confidence score:

0.421
Other information
Title:

Circular RNA hsa_circ_0023404 promotes the proliferation, migration and invasion in endometrial cancer cells through regulating miR-217/MAPK1 axis.

Journal: European journal of medical research
Published: 2022
PubMed ID: 36352482
Study type:

biological research
Data availability: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -