circRNA basic information
circBase ID: hsa_circ_0000467
Name: hsa_circ_SKA3
Synonym: hsa_circRNA_101231
Host Gene: SKA3
Genomic location(hg19): chr13:21742126-21742538:-
Genomic location(hg38): chr13:21167987-21168399:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; cancer adjacent tissues
Cell lines:

HT29; HCT 116; FHC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FADS1
Associated microRNA: miR-330-5p, miR-326, miR-330-3p
Biological function: promotes CRC cell proliferation and migration
Molecular mechanism: potential ceRNA mechanism as an exonic circRNA, involving hsa_circ_0000467/miR-330-5p/FADS1 and hsa_circ_0000467/miR-326/FADS1
Biological pathway or process:

proliferation (promotes); migration (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; MTT; Transwell Assay
Clinical significance:

-
Description:

hsa_circ_0000467 is up-regulated in CRC tissues and cell lines and promotes CRC cell proliferation and migration. The study proposes that hsa_circ_0000467 may function in a ceRNA network involving miR-326/miR-330-5p and the target gene FADS1, supported by expression changes after circRNA knockdown.
Confidence score:

0.5923
Other information
Title:

Hsa_circ_0040809 and hsa_circ_0000467 promote colorectal cancer cells progression and construction of a circRNA-miRNA-mRNA network.

Journal: Frontiers in genetics
Published: 2022
PubMed ID: 36339002
Study type:

combined biological and clinical study
Data availability: GSE126094; GSE138589; GSE142837
Code availability: -