circRNA basic information
circBase ID: hsa_circ_0063331
Name: hsa_circ_DDX17
Synonym: circDDX17
Host Gene: DDX17
Genomic location(hg19): chr22:38894089-38897285:-
Genomic location(hg38): chr22:38498084-38501280:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0023161
MONDO name: viral myocarditis
Disease details: viral myocarditis / VM
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 C128381
Disease ICD11 ID:
 231270764
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

heart tissue
Cell lines:

HeLa; HL-1; HEK-293T
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: NOTCH2, METTL3, METTL14
Associated microRNA: miR-1248
Biological function: promotes CVB3 replication
Molecular mechanism: Acts as a miRNA sponge for miR-1248 to regulate NOTCH2, which upregulates METTL3 (and METTL14), thereby enhancing CVB3 replication.
Biological pathway or process:

viral replication (promotes); ceRNA regulation (promotes); m6A modification (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; Sanger Sequencing; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; Western Blot; Co-IP; Plaque Assay; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

circDDX17 (hsa_circ_0063331), derived from DDX17, is down-regulated after CVB3 infection in cells and in a mouse viral myocarditis model. Functionally, circDDX17 promotes CVB3 replication by sponging miR-1248 to relieve repression of NOTCH2, which is linked to increased METTL3/METTL14 expression.
Confidence score:

0.7924
Other information
Title:

CircDDX17 enhances coxsackievirus B3 replication through regulating miR-1248/NOTCH receptor 2 axis.

Journal: Frontiers in microbiology
Published: 2022
PubMed ID: 36338034
Study type:

combined biological and clinical study
Data availability: -
Code availability: -