| Expression pattern: |
UP |
| Associated gene: |
AGO2 |
| Associated microRNA: |
miR-421, miR-195-5p |
| Biological function: |
promotes CRC cell proliferation, migration and invasion and inhibits apoptosis; counteracts the anti-tumor effects of Caudatin |
| Molecular mechanism: |
acts as a miRNA sponge for miR-421 and miR-195-5p in a Caudatin-regulated pathway |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
associated with lymph node metastasis and tumor-node-metastasis stage; potential diagnostic marker for CRC |
| Description: |
hsa_circ_0060927 is up-regulated in colorectal cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion) and suppresses apoptosis by sponging miR-421 and miR-195-5p, thereby counteracting Caudatin’s anti-tumor effects. |
| Confidence score: |
0.8571 |