circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast tissues; adjacent normal tissues
Cell lines:

MCF-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Diagnostic potential for discriminating breast cancer from normal tissues.
Description:

circHIPK3 is up-regulated in breast cancer tissues versus adjacent normal tissues and is detectable by both the CRISPR nanoswitch and RT-qPCR. In this study it serves as a clinically relevant marker for distinguishing breast cancer from normal tissue.
Confidence score:

0.5261
Other information
Title:

Mirror-synchronized asymmetric CRISPR nanoswitch for single-molecule profiling of multiple circRNAs in different stages of breast cancer.

Journal: Nucleic acids research
Published: 2025
PubMed ID: 41206041
Study type:

combined biological and clinical study
Data availability: Data will be made available on request.
Code availability: -