| Expression pattern: |
UP |
| Associated gene: |
RAC1, PAK1, EIF4A3 |
| Associated microRNA: |
miR-142-3p, miR-142-5p |
| Biological function: |
Promotes breast cancer tumorigenesis and progression by promoting proliferation and migration/metastasis and inhibiting apoptosis. |
| Molecular mechanism: |
circBRWD3 acts as a ceRNA sponge for miR-142-3p and miR-142-5p to upregulate RAC1 and activate RAC1/PAK1 signaling; EIF4A3 binds upstream of BRWD3 pre-mRNA to facilitate circBRWD3 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
circBRWD3 expression was positively correlated with poor prognosis and associated with tumor size, TNM staging, and lymph node metastasis. |
| Description: |
circBRWD3 is upregulated in breast cancer and acts as an oncogenic circRNA. It sponges miR-142-3p/miR-142-5p to increase RAC1 and activate RAC1/PAK1 signaling, promoting proliferation and migration/metastasis while inhibiting apoptosis; EIF4A3 positively regulates circBRWD3 biogenesis. High circBRWD3 expression is associated with poor patient prognosis. |
| Confidence score: |
0.8171 |