| Expression pattern: |
UP |
| Associated gene: |
Ago1, Ago2, Hur, FMRP, EIF4A3 |
| Associated microRNA: |
hsa-miR-320a, hsa-miR-320b, hsa-miR-320c, hsa-miR-320d, hsa-miR-4429 |
| Biological function: |
Cytokine-induced circRNA in human beta cells; predicted to bind beta-cell-enriched miRNAs (including miR-320 family) and RBPs, suggesting potential sponge/decoy roles. |
| Molecular mechanism: |
Predicted circCRIM1-miRNA interactions (StarBase/CLIP-based) and predicted RBP binding sites on junction sequences (CircInteractome). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circCRIM1 (hsa_circ_0002938) is upregulated by cytokines in EndoC-betaH1 cells and validated as circular by RT-qPCR/Sanger sequencing. It is predicted to bind beta-cell-enriched miRNAs (notably the miR-320 family and miR-4429), suggesting a potential sponge/decoy regulatory role during inflammatory stress relevant to T1D. |
| Confidence score: |
0.6193 |