| Expression pattern: |
UP |
| Associated gene: |
Ago1, Ago2, Hur, FMRP, EIF4A3 |
| Associated microRNA: |
- |
| Biological function: |
Cytokine-induced circRNA in human beta cells; functional role not experimentally tested in this study. |
| Molecular mechanism: |
No miRNA binding sites identified for circEPSTI1 by the study’s prediction pipeline; RBP binding sites predicted on junction sequence. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circEPSTI1 (hsa_circ_0000479) is upregulated by cytokine exposure in EndoC-betaH1 cells and detected in human islets, with circularity validated by Sanger sequencing. The study’s bioinformatic analysis did not find miRNA binding sites for circEPSTI1, but predicted RBP binding on its junction sequence. |
| Confidence score: |
0.6193 |