| Expression pattern: |
UP |
| Associated gene: |
NCAM1, CD44, SYP |
| Associated microRNA: |
hsa-miR-296-5p, hsa-miR-1976 |
| Biological function: |
Associated with CRC immunoregulatory ceRNA network and circRNA-protein network linked to macrophage infiltration (functional role not experimentally validated). |
| Molecular mechanism: |
ceRNA network via miRNA sponging affecting hub genes (NCAM1, CD44, SYP). |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Potential diagnostic and therapeutic paradigm for CRC (no circRNA-specific clinical endpoint reported). |
| Description: |
hsa_circ_0000511 (RPPH1-derived) is identified as a co-upregulated circRNA in CRC and incorporated into a predicted ceRNA subnetwork linking it to hsa-miR-296-5p and hsa-miR-1976 with downstream hub genes NCAM1, CD44 and SYP. Its expression is supported by GEO differential expression and qRT-PCR detection in CRC cell lines. |
| Confidence score: |
0.4032 |