circRNA basic information
circBase ID: hsa_circ_0003812
Name: hsa_circ_NEAT1
Synonym: NEAT1_2 circRNA
Host Gene: NEAT1
Genomic location(hg19): chr11:65198239-65205128:+
Genomic location(hg38): chr11:65430768-65437657:+
Subcellular localization: nucleus
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005108
MONDO name: viral infectious disease
Disease details: HSV-1 infection
Disease DO ID:
 934
Disease MeSH ID:
 D014777
Disease NCIt ID:
 C3439
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

primary human foreskin fibroblasts (HFFs); telomerase-immortalized human foreskin fibroblasts (T-HFs); human tracheobronchial epithelial cells (HTBE); monocyte-derived macrophages (MDM)
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Induced back-splicing from the unique 3’ region of NEAT1_2, accompanied by induction of novel linear splicing within and downstream of the circRNA region; biogenesis reflects increased de novo synthesis during HSV-1 and IAV infection (vhs-independent).
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0003812 is a NEAT1_2-derived circRNA whose biogenesis is strongly induced during HSV-1 infection (vhs-independent) and also during influenza A virus infection. Its induction is linked with novel linear splicing events within and downstream of the circRNA region, suggesting coordinated activation of NEAT1_2 circular and linear splicing under these infection conditions.
Confidence score:

0.1768
Other information
Title:

HSV-1 and influenza infection induce linear and circular splicing of the long NEAT1 isoform.

Journal: PloS one
Published: 2022
PubMed ID: 36279270
Study type:

bioinformatics study
Data availability: SRP044766; SRP192356; SRP110623; SRP189489; SRP191795; SRP321121; SRP340110; SRP189262; SRP091886; SRP103821; ERP003815; SRP050333; SRP179971; SRP217721; SRP068450; SRP101458; SRP165924; SRP166943; SRP270819; SRP307127; SRP055770; SRP197110; SRP152310
Code availability: https://github.com/watchdog-wms/watchdog-wms-workflows/tree/master/circRNA_Detection