| Expression pattern: |
UP |
| Associated gene: |
KLF12 |
| Associated microRNA: |
miR-490-3p |
| Biological function: |
Promotes osteosarcoma cell proliferation, migration, invasion and glycolysis under hypoxia; its knockdown inhibits tumor growth and lung metastasis in vivo. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-490-3p, thereby increasing KLF12 expression and promoting hypoxia-associated progression and glycolysis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circCYP51A1 is up-regulated in osteosarcoma tissues and in osteosarcoma cells exposed to hypoxia. It promotes hypoxia-associated proliferation, migration, invasion and glycolysis by sponging miR-490-3p to upregulate KLF12, and its knockdown suppresses xenograft tumor growth (and reduces lung metastatic nodes). |
| Confidence score: |
0.7855 |