circRNA basic information
circBase ID: hsa_circ_0001583
Name: hsa_circ_H1-2
Synonym: -
Host Gene: H1-2
Genomic location(hg19): chr6:26056122-26056299:-
Genomic location(hg38): chr6:26055894-26056071:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast tumor tissue; adjacent nontumor samples / paracancerous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-6815-3p, hsa-miR-324-3p, hsa-miR-103a-2-5p, hsa-miR-4778-3p, hsa-miR-647
Biological function: May serve as a biomarker for breast cancer and may modulate tumor immunology through a ceRNA mechanism.
Molecular mechanism: Predicted ceRNA network (hsa_circ_0001583-miRNA-mRNA); associated with immune response pathways by KEGG analysis.
Biological pathway or process:

immune regulation (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Proposed as a novel biomarker for BC diagnosis; significantly up-regulated in BC tissues vs paired adjacent tissues.
Description:

hsa_circ_0001583 is significantly up-regulated in breast cancer tissues and is proposed as a diagnostic biomarker. The study predicts a hsa_circ_0001583-miRNA-mRNA ceRNA network and links it to immune-related pathways by enrichment analysis.
Confidence score:

0.4032
Other information
Title:

Microarray Profile of Circular RNAs Identifies hsa_circ_0001583 as A New Circular RNA Biomarker for Breast Cancer: A Retrospective Study.

Journal: Cell journal
Published: 2022
PubMed ID: 36274202
Study type:

combined biological and clinical study
Data availability: GSE165884
Code availability: -