| Expression pattern: |
UP |
| Associated gene: |
SLC1A5, c-Myc, MMP9 |
| Associated microRNA: |
hsa_miR-370-3p |
| Biological function: |
promotes proliferation, invasion, angiogenesis and glutamine metabolism; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0025033 sponges hsa_miR-370-3p to regulate SLC1A5 expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); glutaminolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high level of circ_0025033 was predictive of poor prognosis in sufferers of ovarian cancer |
| Description: |
circ_0025033 is up-regulated in ovarian cancer and promotes malignant phenotypes (proliferation, invasion, angiogenesis, glutamine metabolism) while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging hsa_miR-370-3p to de-repress SLC1A5, and its high expression predicts poor prognosis. |
| Confidence score: |
0.8354 |