circRNA basic information
circBase ID: -
Name: hsa_circ_AKT2
Synonym: circAKT2
Host Gene: AKT2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MDA-MB-231
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: not specified
Biological pathway or process:

PI3K/AKT (other)
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

-
Description:

In MDA-MB-231 breast cancer cells treated with drugs, circAKT2 increases while the linear AKT2 isoform decreases. The study links this observation to the PI3K/AKT pathway context but notes that circAKT2’s functional role remains unclear.
Confidence score:

0.1155
Other information
Title:

Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.

Journal: Non-coding RNA
Published: 2023
PubMed ID: 37218992
Study type:

biological research
Data availability: All data used to support the conclusions are included in the manuscript.
Code availability: -