circRNA basic information
circBase ID: hsa_circ_0001756
Name: hsa_circ_HIPK2
Synonym: circHIPK2
Host Gene: HIPK2
Genomic location(hg19): chr7:139415730-139416814:-
Genomic location(hg38): chr7:139715931-139717015:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015459
MONDO name: nasopharyngeal carcinoma
Disease details: nasopharyngeal carcinoma / NPC
Disease DO ID:
 9261
Disease MeSH ID:
 D00007727; D000077274
Disease NCIt ID:
 C3871
Disease ICD11 ID:
 1883313543
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NPC tissues; normal nasopharyngeal tissues
Cell lines:

CNE; CNE-2; 5-8F; 6-10B; NP69
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HIPK2, beta-catenin
Associated microRNA: -
Biological function: promotes proliferation and tumor growth of nasopharyngeal carcinoma cells
Molecular mechanism: circHIPK2 inhibits HIPK2 protein level post-transcriptionally, thereby increasing beta-catenin protein level to promote NPC proliferation
Biological pathway or process:

proliferation (promotes); Wnt/beta-catenin (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; Transfection; CCK8; Colony Formation Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Western Blot; In Vivo Animal Model
Clinical significance:

circHIPK2 might be a novel treatment target for NPC management
Description:

circHIPK2 (hsa_circ_0001756), derived from HIPK2, is up-regulated in nasopharyngeal carcinoma tissues and promotes NPC cell proliferation and xenograft tumor growth. Mechanistically, circHIPK2 post-transcriptionally suppresses HIPK2 protein and increases beta-catenin protein levels, supporting an oncogenic circHIPK2/HIPK2 axis.
Confidence score:

0.5949
Other information
Title:

CircHIPK2 promotes proliferation of nasopharyngeal carcinoma by down-regulating HIPK2.

Journal: Translational cancer research
Published: 2022
PubMed ID: 35966290
Study type:

combined biological and clinical study
Data availability: unpublished data; https://tcr.amegroups.com/article/view/10.21037/tcr-22-1645/dss
Code availability: -