circRNA basic information
circBase ID: -
Name: hsa_circ_RNF220
Synonym: circRNF220
Host Gene: RNF220
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatitis B virus-driven hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Hep3B; HepG2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Significantly upregulated validated circRNA in HBV-integrated Hep3B cells; specific functional mechanism was not reported.
Molecular mechanism: Not specifically defined for circRNF220 beyond inclusion among upregulated bona fide circRNAs.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq
Clinical significance:

-
Description:

circRNF220 was one of the selected and experimentally validated upregulated circRNAs in HBV-integrated Hep3B cells. The paper confirms its dysregulated expression and back-splice junction but does not define a specific miRNA, mRNA, pathway, or clinical role for circRNF220.
Confidence score:

0.437
Other information
Title:

Decoding the circRNA-miRNA-mRNA regulatory network in hepatitis B virus-driven hepatocellular carcinoma.

Journal: Cell communication and signaling : CCS
Published: 2026
PubMed ID: 41845440
Study type:

combined biological and bioinformatics study
Data availability: All the data are available from the corresponding author upon request.
Code availability: -