| Expression pattern: |
UP |
| Associated gene: |
PDK1, BCL11A, Ago2 |
| Associated microRNA: |
miR-1231 |
| Biological function: |
promotes NKTL progression and glycolysis (glucose uptake and lactate production) |
| Molecular mechanism: |
circKIF4A acts as a ceRNA/miRNA sponge for miR-1231 to regulate PDK1 and BCL11A expression |
| Biological pathway or process: |
glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circKIF4A levels predict poorer OS and PFS and circKIF4A expression is an independent prognostic indicator of NKTL |
| Description: |
circKIF4A is up-regulated in NKTL and high expression is associated with worse OS/PFS. Functionally, circKIF4A promotes NKTL glycolysis (glucose uptake and lactate production) by acting as a ceRNA that sponges miR-1231, thereby increasing PDK1 and BCL11A expression. |
| Confidence score: |
0.8487 |