| Expression pattern: |
UP |
| Associated gene: |
KPNA2, CHAF1A |
| Associated microRNA: |
miR-17-5p, miR-20a-5p, miR-93-5p, miR-519d-3p |
| Biological function: |
Promotes HCC cell viability and motility; promotes KPNA2 expression via ceRNA activity. |
| Molecular mechanism: |
Acts as a ceRNA (miRNA sponge) for multiple miRNAs to regulate KPNA2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Transfection; CCK8; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0001345 is upregulated in HCC and supports HCC cell proliferation/motility. Mechanistically, it acts as a ceRNA that sponges miR-17-5p/miR-20a-5p/miR-93-5p/miR-519d-3p to promote KPNA2 expression. |
| Confidence score: |
0.593 |