| Expression pattern: |
UP |
| Associated gene: |
Hornerin, METTL1, PI3K |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation; promotes colony formation/tumorigenesis; promotes migration; promotes invasion; promotes metastasis; promotes tumor growth |
| Molecular mechanism: |
METTL1-mediated m7G modification increases circIPP2A2 stability and enhances its binding; circIPP2A2 serves as a molecular scaffold facilitating Hornerin-PI3K interaction, thereby activating PI3K/AKT/GSK3beta signaling. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); m7G modification (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); Co-IP; In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circIPP2A2 high expression was associated with multiple tumor numbers and predicted poorer overall survival and disease-free survival following surgery; circIPP2A2 high expression was an independent risk factor for OS. |
| Description: |
circIPP2A2 is up-regulated in HCC and promotes tumor growth and metastasis. METTL1-mediated m7G modification increases circIPP2A2 stability and supports its binding, enabling circIPP2A2 to act as a scaffold that strengthens Hornerin-PI3K interaction and activates PI3K/AKT/GSK3beta signaling. High circIPP2A2 expression is associated with worse postoperative survival. |
| Confidence score: |
0.8785 |