| Expression pattern: |
UP |
| Associated gene: |
PD-L1, CDK4, CDK6 |
| Associated microRNA: |
miR-34a |
| Biological function: |
promotes AML cell proliferation |
| Molecular mechanism: |
circ_POLA2 suppresses the maturation/production of mature miR-34a, leading to increased PD-L1 expression and enhanced proliferation. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; BrdU; Cell Cycle Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Patients with higher expression levels of circ_POLA2 had lower overall survival rate. |
| Description: |
circ_POLA2 is upregulated in AML bone marrow samples and AML cell lines, and its high expression is associated with worse overall survival. Functionally, circ_POLA2 promotes AML cell proliferation, at least in part by suppressing the production/maturation of mature miR-34a and increasing PD-L1 expression. |
| Confidence score: |
0.6458 |