| Expression pattern: |
UP |
| Associated gene: |
MSI1 |
| Associated microRNA: |
miR-296-5p |
| Biological function: |
promotes tumorigenesis (increases proliferation, promotes cell cycle progression, reduces apoptosis) and suppresses radiosensitivity (promotes survival/colony formation and inhibits radiation-induced apoptosis) in colorectal cancer |
| Molecular mechanism: |
ceRNA sponge mechanism: circ_IFT80 sponges miR-296-5p to relieve repression of MSI1, thereby promoting tumorigenesis and radioresistance |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); radioresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; Transfection; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Colony Formation Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
potential biomarker for diagnosis or treatment for CRC |
| Description: |
circ_IFT80 is up-regulated in CRC patient serum-derived exosomes and CRC cells. It promotes CRC tumorigenesis and radioresistance by acting as a ceRNA sponge for miR-296-5p, thereby increasing MSI1 expression and enhancing proliferation/cell-cycle progression while suppressing apoptosis. |
| Confidence score: |
0.7181 |