circRNA basic information
circBase ID: hsa_circ_0008812
Name: hsa_circ_RAD23B
Synonym: circ_0008812
Host Gene: RAD23B
Genomic location(hg19): chr9:110062421-110074018:+
Genomic location(hg38): chr9:107300140-107311737:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent normal tissues
Cell lines:

MCF-7; MCF-10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RACGAP1
Associated microRNA: miR-4554-3p
Biological function: promotes breast cancer cell proliferation
Molecular mechanism: ceRNA mechanism (predicted prognostic axis) involving miR-4554-3p and RACGAP1
Biological pathway or process:

proliferation (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Transfection; MTT; Colony Formation Assay; Survival Analysis
Clinical significance:

Upregulation of circ_0008812 predicts poor prognosis in breast cancer patients
Description:

circ_0008812 is up-regulated in breast cancer datasets and is highly expressed in MCF-7 cells. siRNA-mediated knockdown suppresses MCF-7 proliferation, and the study proposes a prognostic ceRNA axis circ_0008812/miR-4554-3p/RACGAP1 linked to poor prognosis.
Confidence score:

0.5923
Other information
Title:

Upregulation of circ_0008812 and circ_0001583 predicts poor prognosis and promotes breast cancer proliferation.

Journal: Frontiers in molecular biosciences
Published: 2022
PubMed ID: 36200070
Study type:

combined biological and clinical study
Data availability: GSE165884; GSE182471; TCGA
Code availability: -