| Expression pattern: |
UP |
| Associated gene: |
WT1 |
| Associated microRNA: |
miR-149-5p |
| Biological function: |
promotes proliferation, invasion and tumor growth; inhibits apoptosis and autophagy; mediates the anti-tumor effect of aloin when suppressed |
| Molecular mechanism: |
ceRNA mechanism; sponges miR-149-5p and regulates WT1 expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); autophagy (inhibits); drug resistance (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; In Vivo Animal Model; Western Blot; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; IF (Immunofluorescence); IHC (Immunohistochemistry) |
| Clinical significance: |
Aloin may be a potential candidate drug for HCC treatment. |
| Description: |
circ_0011385 was upregulated in HCC and acted as an oncogenic circRNA that counteracted the anti-tumor effect of aloin. It functioned as a miR-149-5p sponge to increase WT1 expression, thereby promoting HCC cell proliferation and invasion while suppressing apoptosis and autophagy. |
| Confidence score: |
0.7092 |