circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: circPVT1
Host Gene: PVT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002108
MONDO name: thyroid cancer
Disease details: thyroid cancer / TC
Disease DO ID:
 1781
Disease MeSH ID:
 -
Disease NCIt ID:
 C7510
Disease ICD11 ID:
 447433352
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

thyroid cancer tissue; adjacent normal tissue (ANT)
Cell lines:

TPC-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-384
Biological function: promotes proliferation, colony formation, migration and invasion of thyroid cancer cells
Molecular mechanism: ceRNA (miRNA sponge) mechanism via binding miR-384
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down Assay; Bioinformatics Analysis; Clinical Sample Validation; Survival Analysis
Clinical significance:

circPVT1 expression was associated with clinical stage and lymph node metastasis; associated with poor prognosis
Description:

circPVT1 is up-regulated in thyroid cancer and functions as an oncogenic circRNA, promoting proliferation, colony formation, migration and invasion. Mechanistically, it mainly localizes in the cytoplasm and sponges miR-384, and miR-384 inhibition partially rescues the effects of circPVT1 knockdown. High circPVT1 expression correlates with advanced TNM stage, lymph node metastasis, and poor prognosis.
Confidence score:

0.7718
Other information
Title:

Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR-384.

Journal: Experimental and therapeutic medicine
Published: 2022
PubMed ID: 36185502
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -