| Expression pattern: |
DN |
| Associated gene: |
SMAD4 |
| Associated microRNA: |
miR-766 |
| Biological function: |
restrains tumor growth and enhances radiosensitivity by inhibiting proliferation, inducing G0/G1 arrest, promoting irradiation-induced apoptosis, and suppressing EMT |
| Molecular mechanism: |
ceRNA mechanism: circ_ITGA7 sponges miR-766 to relieve repression of SMAD4 (prevents SMAD4 degradation), increasing SMAD4 expression |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (inhibits); apoptosis (promotes); EMT (inhibits); ceRNA regulation (other); radioresistance (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Cell Cycle Assay; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High circ_ITGA7 expression is associated with longer overall survival in CRC patients |
| Description: |
circ_ITGA7 is down-regulated in colorectal cancer and higher expression correlates with longer overall survival. Functionally, circ_ITGA7 suppresses CRC growth and increases radiosensitivity by sponging miR-766 to up-regulate SMAD4, leading to reduced proliferation, G0/G1 arrest, increased irradiation-induced apoptosis, and inhibition of EMT. |
| Confidence score: |
0.7859 |