| Expression pattern: |
UP |
| Associated gene: |
SphK1, CDK4, STAT3 |
| Associated microRNA: |
miR-124 |
| Biological function: |
Promotes lung cancer cell survival and proliferation and inhibits apoptosis; circHIPK3 knockdown inhibits survival and proliferation and induces apoptosis in lung cancer cells. |
| Molecular mechanism: |
circHIPK3 acts as a miR-124 sponge and regulates miR-124 target mRNAs and proteins, including SphK1, STAT3 and CDK4. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; BrdU; EdU Staining; TUNEL; ELISA; Western Blot |
| Clinical significance: |
circHIPK3 is upregulated in human lung cancer tissues and may represent a therapeutic strategy involving the circHIPK3-miR-124 pathway against lung cancer. |
| Description: |
circHIPK3 is upregulated in human lung cancer cells and tissues. It promotes lung cancer cell survival and proliferation while suppressing apoptosis, likely by sponging miR-124 and derepressing miR-124 targets including SphK1, STAT3 and CDK4. The study suggests the circHIPK3-miR-124 axis as a potential therapeutic target in lung cancer. |
| Confidence score: |
0.5442 |