circRNA basic information
circBase ID: -
Name: -
Synonym: chr12:130827535-130846146+ / (novel)
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0850098
MONDO name: oligoasthenoteratozoospermia
Disease details: oligoasthenospermia / OAZ
Disease DO ID:
 0070311
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

seminal plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: SEPT1
Associated microRNA: hsa-miR-7111-3p, hsa-miR-3653-5p, hsa-miR-6071, hsa-miR-758-3p, hsa-miR-3164
Biological function: -
Molecular mechanism: Predicted circRNA-miRNA-mRNA network (miRNA sponge/ceRNA).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential diagnostic value as exosomal circRNA biomarker for OAZ.
Description:

This novel exosomal circRNA (chr12:130827535-130846146+) is differentially expressed in seminal plasma exosomes from OAZ patients and was validated by RT-qPCR. It was incorporated into a predicted circRNA-miRNA-mRNA network consistent with a potential ceRNA mechanism, and SEPT1 was tested as an associated target gene.
Confidence score:

0.4032
Other information
Title:

Functional prediction and profiling of exosomal circRNAs derived from seminal plasma for the diagnosis and treatment of oligoasthenospermia.

Journal: Experimental and therapeutic medicine
Published: 2022
PubMed ID: 36168415
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -