| Expression pattern: |
UP |
| Associated gene: |
RNF187, STAT3, IL-6 |
| Associated microRNA: |
miR-890 |
| Biological function: |
promotes propranolol resistance and proliferation, and inhibits apoptosis in haemangioma derived stem cells (HemSCs) |
| Molecular mechanism: |
Transcriptionally induced by IL-6-activated STAT3; acts as a ceRNA (miR-890 sponge) to relieve miR-890 repression of RNF187, resulting in RNF187 upregulation and propranolol resistance |
| Biological pathway or process: |
ceRNA regulation (promotes); apoptosis (inhibits); proliferation (promotes); drug resistance (promotes); JAK/STAT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; CCK8; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; ChIP / ChIP-seq; RNA Pull-Down; Nuclear-Cytoplasmic Fractionation; Transfection; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
Circ_0000915 was higher in IH tissues (especially propranolol-resistant patients) and positively associated with propranolol resistance |
| Description: |
hsa_circ_0000915 (Circ_0000915), derived from FKBP8, is up-regulated in infantile haemangioma tissues and is higher in propranolol-resistant cases. It promotes propranolol resistance in HemSCs by being transcriptionally activated via IL-6/STAT3 and acting as a cytoplasmic miR-890 sponge to de-repress RNF187. |
| Confidence score: |
0.7322 |