circRNA basic information
circBase ID: -
Name: hsa_circ_DPF3
Synonym: circDPF3 / hsa_circ:chr14:73181131-73198642
Host Gene: DPF3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumor tissues; matched peritumor tissues; healthy liver tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May participate in HCC progression (functional mechanism not further studied).
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

circRNA-seq; Bioinformatics Analysis; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

May differentiate HCC tumor tissues from healthy liver tissues (AUC=0.946); no significant correlation with investigated clinical characteristics or outcomes.
Description:

circDPF3 is significantly down-regulated in HCC tumor tissues versus matched peritumor tissues and healthy liver tissues, and it may be involved in HCC progression. The study did not further validate a mechanism or functional role for circDPF3 beyond expression/diagnostic analyses.
Confidence score:

0.6238
Other information
Title:

Circular RNA profiling identifies circADAMTS13 as a miR-484 sponge which suppresses cell proliferation in hepatocellular carcinoma.

Journal: Molecular oncology
Published: 2019
PubMed ID: 30537115
Study type:

combined biological and clinical study
Data availability: -
Code availability: -