| Expression pattern: |
UP |
| Associated gene: |
JPT1, Ago2 |
| Associated microRNA: |
miR-513b-5p |
| Biological function: |
circLPAR3 promotes PCa cell proliferation, migration, invasion and glycolysis, represses apoptosis and radiosensitivity, and is associated with poor prognosis. |
| Molecular mechanism: |
circLPAR3 acts as a ceRNA sponge for miR-513b-5p to up-regulate JPT1, thereby facilitating PCa advancement and glycolysis and repressing radiosensitivity. |
| Biological pathway or process: |
ceRNA regulation (other); glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); radioresistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
High circLPAR3 expression is associated with high Gleason score, advanced pathological T stage, distant metastases and lower survival rate, suggesting poor prognosis and potential biomarker value. |
| Description: |
circLPAR3 is up-regulated in prostate cancer tissues and cell lines and high expression is linked to worse clinicopathological features and poor survival. Functionally, circLPAR3 promotes PCa cell advancement and glycolysis while reducing radiosensitivity. Mechanistically, it acts as a sponge for miR-513b-5p to regulate JPT1 in the circLPAR3/miR-513b-5p/JPT1 axis. |
| Confidence score: |
0.8463 |