| Expression pattern: |
UP |
| Associated gene: |
CACUL1 |
| Associated microRNA: |
miR-147a |
| Biological function: |
Promotes colorectal cancer cell proliferation and progression; its knockdown induces G1/S cell cycle arrest and apoptosis. |
| Molecular mechanism: |
ceRNA mechanism: circZFR sponges miR-147a to regulate CACUL1 expression, affecting cell cycle and apoptosis. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Western Blot; TUNEL |
| Clinical significance: |
circZFR might be a therapeutic target and biomarker for CC. |
| Description: |
circZFR is up-regulated in colorectal cancer cell lines and functions as an oncogenic circRNA. It sponges miR-147a to relieve repression of CACUL1, thereby promoting proliferation and suppressing apoptosis while facilitating G1/S cell-cycle progression. |
| Confidence score: |
0.5627 |