| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-23a, miR-23b, miR-581, miR-146a, miR-450a |
| Biological function: |
May be involved in GC tumorigenesis and may regulate transcription-related biological functions (RNA metabolism, gene expression, gene silencing). |
| Molecular mechanism: |
Predicted ceRNA/miRNA sponge mechanism via a circRNA-miRNA-gene network (TargetScan/miRanda predictions). |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
A promising biomarker for GC diagnosis and targeted therapy. |
| Description: |
hsa_circ_0000026 (EIF4G3-derived; also referred to as circRNA-0026/circ_000026) is significantly down-regulated in gastric cancer tissues versus adjacent normal tissues. The study predicts it may function through a circRNA-miRNA-mRNA network (miR-23a/miR-23b/miR-581/miR-146a/miR-450a), potentially influencing transcription-related processes, and suggests it as a diagnostic biomarker candidate. |
| Confidence score: |
0.585 |