circRNA basic information
circBase ID: -
Name: hsa_circ_TFRC
Synonym: hsa_circRNA_103554
Host Gene: TFRC
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006952
MONDO name: retinopathy of prematurity
Disease details: retinopathy of prematurity / ROP
Disease DO ID:
 13025
Disease MeSH ID:
 D012178
Disease NCIt ID:
 C34982
Disease ICD11 ID:
 947283385
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TFRC
Associated microRNA: -
Biological function: potential diagnostic biomarker for treatment-requiring ROP
Molecular mechanism: possible involvement via host gene TFRC in iron homeostasis and angiogenesis (hypothesized)
Biological pathway or process:

angiogenesis (other); mitochondrial function (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

ROC curve analysis showed AUC 0.8822 for diagnosis of ROP (cutoff <0.0005235; sensitivity 91.67%; specificity 73.91%).
Description:

hsa_circRNA_103554 is significantly down-regulated in PBMCs from treatment-requiring ROP infants and serves as a potential diagnostic biomarker (AUC ~0.88). The paper notes TFRC as its host gene and discusses a possible link to angiogenesis/mitochondrial function via TFRC, but does not experimentally validate a specific mechanism for the circRNA.
Confidence score:

0.5047
Other information
Title:

Potential biomarkers for retinopathy of prematurity identified by circular RNA profiling in peripheral blood mononuclear cells.

Journal: Frontiers in immunology
Published: 2022
PubMed ID: 36081509
Study type:

combined biological and clinical study
Data availability: GSE204780
Code availability: -