| Expression pattern: |
UP |
| Associated gene: |
USP5, AGO2, beta-catenin, c-Myc, ASCT2, GLS1 |
| Associated microRNA: |
miR-1256 |
| Biological function: |
promotes glutaminolysis, proliferation, migration, and invasion; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circHECTD1 sponges miR-1256 to upregulate USP5, activating beta-catenin/c-Myc signaling and enhancing glutaminolysis |
| Biological pathway or process: |
glutaminolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); Wnt/beta-catenin (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; FISH / smFISH; RNase R Treatment; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circHECTD1 expression was associated with lymph node metastasis and AJCC stage, and high circHECTD1 predicted poor overall survival and was an independent prognostic factor in GC patients |
| Description: |
circHECTD1 is upregulated in gastric cancer and acts as an oncogenic circRNA. It sponges miR-1256 to increase USP5 expression, activating beta-catenin/c-Myc signaling to enhance glutaminolysis and promote proliferation, migration, invasion, and tumor growth; high circHECTD1 predicts poor prognosis. |
| Confidence score: |
0.8715 |