circRNA basic information
circBase ID: hsa_circ_0005870
Name: hsa_circ_SETD2
Synonym: -
Host Gene: SETD2
Genomic location(hg19): chr3:47079155-47088111:-
Genomic location(hg38): chr3:47037665-47046621:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018695
MONDO name: avian influenza
Disease details: avian influenza virus infection / AIV infection
Disease DO ID:
 4492
Disease MeSH ID:
 D005585
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549 cells; 293T cells
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: has-miR-141-5p, has-miR-874-3p
Biological function: restricts AIV replication and proliferation; acts as a host barrier (antiviral) against AIV
Molecular mechanism: may function via ceRNA network by sponging miRNAs to regulate host mRNAs; associated with cell cycle process
Biological pathway or process:

cell cycle (inhibits); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Agarose Gel Electrophoresis; Transfection; Western Blot
Clinical significance:

-
Description:

hsa_circ_0005870 is induced by avian-origin influenza virus in human cells and shows antiviral activity: knockdown promotes, while overexpression suppresses AIV (H9N2) replication. It may act through a ceRNA mechanism by sponging specific miRNAs to influence host mRNA programs linked to the cell cycle.
Confidence score:

0.6073
Other information
Title:

RNA Sequencing Demonstrates That Circular RNA Regulates Avian Influenza Virus Replication in Human Cells.

Journal: International journal of molecular sciences
Published: 2022
PubMed ID: 36077296
Study type:

biological research
Data availability: PRJNA868213
Code availability: -