circRNA basic information
circBase ID: hsa_circ_0003270
Name: hsa_circ_GAPVD1
Synonym: circGAPVD1
Host Gene: GAPVD1
Genomic location(hg19): chr9:128099296-128099870:+
Genomic location(hg38): chr9:125337017-125337591:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes; tumor tissues; normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: GLU, FOSL2, GALNT6, NOP2
Associated microRNA: hsa-miR-532-3p, hsa-miR-5047
Biological function: potential diagnostic biomarker; associated with lymph node metastasis and TNM stage
Molecular mechanism: ceRNA network (circRNA-miRNA-mRNA)
Biological pathway or process:

ceRNA regulation (other); JAK/STAT (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Back-Splice Junction PCR / divergent primers PCR; In Vivo Animal Model
Clinical significance:

circGAPVD1 in plasma exosomes has potential diagnostic value for CRC; high expression correlated with lymph node metastasis and TNM stage
Description:

circGAPVD1 (hsa_circ_0003270) is up-regulated in plasma exosomes from colorectal cancer patients and shows diagnostic performance by ROC analysis. Higher circGAPVD1 levels correlate with lymph node metastasis and advanced TNM stage, and bioinformatic ceRNA modeling links circGAPVD1 with miRNAs (e.g., hsa-miR-532-3p, hsa-miR-5047) and downstream mRNAs (GLU, FOSL2, GALNT6, NOP2).
Confidence score:

0.6616
Other information
Title:

Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer.

Journal: Translational oncology
Published: 2023
PubMed ID: 36934637
Study type:

combined biological and clinical study
Data availability: GSE126094; GSE126093; GSE126092
Code availability: -